PLEK

Across TCGA cell cohorts, PLEK protein abundance is significantly associated with the RNA expression of many other genes, with 3,650 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLEK-associated genes across cancer lineages are PLPP2, ZC3H12B, and BTBD10. Each is linked with PLEK in more than 4 cancer types. Because this analysis shows association rather than direction, both PLEK-to-partner and partner-to-PLEK results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEK versus PLPP2 in LIVER, with a Pearson correlation of -0.71.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEK→partner) and Y-score (partner→PLEK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PLPP2 →	-3.149	-1.266	.002	.003	2	5
BLOOD_Leukemia	ZC3H12B →	-0.743	-0.838	<.001	<.001	3	4
BLOOD_Myeloma	BTBD10 →	-0.718	-0.878	<.001	.001	3	4
BLOOD_Myeloma	GOLGA6L9 →	-1.237	-0.923	<.001	.002	3	4
BLOOD_Myeloma	GOLGA6L10 →	-0.993	-0.932	.001	.001	3	4
LUNG_NSCLC_LUAD	NBEAL2 →	-1.466	-1.099	.009	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,650 associations by consensus.

PLEK vs PLPP2 — LIVER

Explore this scatter interactively →