PLEK

Across TCGA cell cohorts, PLEK protein abundance is significantly associated with the go_rna of many other GO terms, with 1,814 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLEK-associated GO terms across cancer lineages are Toll-like receptor TLR6:TLR2 signaling pathway, Ribonucleotide biosynthetic process, and Negative regulation of B cell apoptotic process. Each is linked with PLEK in more than 4 cancer types. Because this analysis shows association rather than direction, both PLEK-to-partner and partner-to-PLEK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Toll-like receptor TLR6:TLR2 signaling pathway grouped by PLEK-low versus PLEK-high in BLOOD_Leukemia.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEK→partner) and Y-score (partner→PLEK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Toll-like receptor TLR6:TLR2 signaling pathway →	-0.118	-0.652	.006	.001	2	5
BLOOD_Lymphoma	Ribonucleotide biosynthetic process →	-0.056	-0.993	.005	.002	3	4
STOMACH	Negative regulation of B cell apoptotic process →	+0.177	+0.935	<.001	.006	3	4
LUNG_NSCLC_LUAD	Regulation of ribosome biogenesis →	-0.068	-0.783	.006	.004	2	4
BLOOD_Lymphoma	Protein oxidation →	+0.869	+0.685	.001	.003	3	3
BLOOD_Lymphoma	Regulation of protein autoubiquitination →	-0.137	-0.798	.004	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,814 associations by consensus.

Toll-like receptor TLR6:TLR2 signaling pathway by PLEK expression — BLOOD_Leukemia

Explore this box plot interactively →