PLEK

Across TCGA cell cohorts, PLEK mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PLEK-associated genes across cancer lineages are TMCO5A, PDILT, and GPR33. Each is linked with PLEK in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEK-to-partner and partner-to-PLEK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMCO5A grouped by PLEK-low versus PLEK-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEK→partner) and Y-score (partner→PLEK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMCO5A →	+0.019	+4.415	<.001	.007	3	2
LUNG_SCLC	PDILT →	+0.102	+4.643	<.001	.004	3	1
LUNG_SCLC	GPR33 →	+0.021	+4.044	.003	.009	3	1
LUNG_SCLC	TMEM247 →	+0.256	+4.523	<.001	.003	3	1
LUNG_NSCLC_LUAD	FHL5 →	+0.023	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	RESP18 →	+0.033	+4.947	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

TMCO5A by PLEK expression — LARGE_INTESTINE

Explore this box plot interactively →