PLD2

Across TCGA patient cohorts, PLD2 mutation is significantly associated with the RNA expression of many other genes, with 5,098 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLD2-associated genes across cancer lineages are POLH-AS1, RN7SKP261, and NUTF2P8. Each is linked with PLD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLD2-to-partner and partner-to-PLD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLH-AS1 grouped by PLD2-low versus PLD2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLD2→partner) and Y-score (partner→PLD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	POLH-AS1 →	+0.659	+3.335	<.001	.005	3	3
COAD	RN7SKP261 →	+0.272	+3.092	<.001	.003	3	2
UCEC	NUTF2P8 →	+0.091	+1.982	<.001	.001	3	2
UCEC	SENP3-EIF4A1 →	+0.069	+1.649	.005	<.001	3	2
UCEC	KMT5AP1 →	+0.177	+1.747	<.001	.005	3	2
UCEC	RASSF1-AS1 →	+0.426	+2.043	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,098 associations by consensus.

POLH-AS1 by PLD2 expression — COAD

Explore this box plot interactively →