PLD1

Across TCGA patient cohorts, PLD1 mutation is significantly associated with the RNA expression of many other genes, with 4,702 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLD1-associated genes across cancer lineages are GINS3, CABS1, and URGCP-MRPS24. Each is linked with PLD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLD1-to-partner and partner-to-PLD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GINS3 grouped by PLD1-low versus PLD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLD1→partner) and Y-score (partner→PLD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GINS3 →	+0.524	+2.462	<.001	<.001	3	4
LIHC	CABS1 →	+0.107	+5.547	<.001	<.001	3	3
UCEC	URGCP-MRPS24 →	+0.223	+1.621	<.001	<.001	3	3
UCEC	TAF9 →	+0.553	+2.000	<.001	<.001	3	3
COAD	KRTAP9-6 →	+0.019	+2.787	.004	.005	3	3
UCEC	FCER1A →	-0.542	-1.784	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,702 associations by consensus.

GINS3 by PLD1 expression — UCEC

Explore this box plot interactively →