PLD1

Across TCGA pan-cancer cohorts, PLD1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PLD1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PLD1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PLD1 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

KIRC, COAD, and LUSC are the cancer types where PLD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.811	<.001	11	view →
COAD	Female	All	−1.260	<.001	8	view →
LUSC	Female	All	+1.761	<.001	7	view →
THCA	Male	II,III,IV	−0.685	<.001	7	view →
UCEC	All	All	−1.103	<.001	6	view →
BRCA	All	III,IV	−0.949	<.001	6	view →
HNSC	Female	II,III,IV	+0.521	.020	4	view →
READ	Male	All	−0.399	.023	4	view →
LUAD	All	All	+0.272	.008	3	view →
CHOL	All	All	+1.373	.001	2	view →
PRAD	All	All	−0.568	<.001	2	view →
LIHC	Male	II,III,IV	−0.782	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PLD1–KIRC

Open the KIRC breakdown →