PLD1

Across TCGA patient cohorts, PLD1 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLD1-associated genes across cancer lineages are PCNA, Cyclin-B1, and Caspase-7-cleavedD198. Each is linked with PLD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLD1-to-partner and partner-to-PLD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PLD1-low versus PLD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLD1→partner) and Y-score (partner→PLD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.144	+1.584	.019	.032	3	4
UCEC	Cyclin-B1 →	+0.486	+2.321	.002	.005	3	4
UCEC	Caspase-7-cleavedD198 →	+0.400	+1.412	.017	.010	3	3
COAD	EGFR_pY1068 →	-0.426	-2.991	.012	.036	3	2
COAD	MSH6 →	-0.714	-2.974	<.001	.036	3	2
COAD	MYH11 →	-1.921	-2.991	.004	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

PCNA by PLD1 expression — UCEC

Explore this box plot interactively →