PLD1

Across TCGA cell cohorts, PLD1 mutation is significantly associated with the RNA expression of many other genes, with 385 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLD1-associated genes across cancer lineages are GALP, F9, and INSL4. Each is linked with PLD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLD1-to-partner and partner-to-PLD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GALP grouped by PLD1-low versus PLD1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLD1→partner) and Y-score (partner→PLD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GALP →	+0.610	+5.357	<.001	.003	3	2
LUNG_SCLC	F9 →	+0.022	+4.058	<.001	.007	3	1
LUNG_SCLC	INSL4 →	+0.041	+3.736	<.001	.007	3	1
LUNG_SCLC	OR9I1 →	+0.013	+4.058	<.001	.007	3	1
LUNG_SCLC	OR10Q1 →	+0.392	+4.058	.001	.007	3	1
LUNG_SCLC	ODF4 →	+0.111	+3.523	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 385 associations by consensus.

GALP by PLD1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →