PLCZ1

Across TCGA patient cohorts, PLCZ1 protein abundance is significantly associated with the RNA expression of many other genes, with 4,029 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PLCZ1-associated genes across cancer lineages are SNRPD3, TRIOBP, and MIEF1. Each is linked with PLCZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCZ1-to-partner and partner-to-PLCZ1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLCZ1 versus SNRPD3 in PDAC, with a Pearson correlation of -0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCZ1→partner) and Y-score (partner→PLCZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SNRPD3 →	-0.264	-0.597	.001	.002	3	1
PDAC	TRIOBP →	-0.263	-0.622	.003	.001	3	1
PDAC	MIEF1 →	-0.261	-0.567	.002	.003	3	1
PDAC	L3MBTL2 →	-0.268	-0.561	.004	.004	3	1
PDAC	KHNYN →	-0.406	-0.741	<.001	<.001	3	1
PDAC	RBM23 →	-0.295	-0.863	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,029 associations by consensus.

PLCZ1 vs SNRPD3 — PDAC

Explore this scatter interactively →