PLCZ1

Across TCGA patient cohorts, PLCZ1 protein abundance is significantly associated with the protein abundance of many other proteins, with 11,371 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PLCZ1-associated proteins across cancer lineages are REEP4_S253, REPS2_S254, and RFTN1_S485. Each is linked with PLCZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCZ1-to-partner and partner-to-PLCZ1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLCZ1 versus REEP4_S253 in PDAC, with a Pearson correlation of 0.67.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCZ1→partner) and Y-score (partner→PLCZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	REEP4_S253 →	+0.965	+0.960	<.001	.002	3	1
PDAC	REPS2_S254 →	-1.163	-0.964	.001	<.001	3	1
PDAC	RFTN1_S485 →	+0.803	+1.646	<.001	.001	3	1
PDAC	RGS14_S199 →	+0.373	+0.716	.002	<.001	3	1
PDAC	RGS14_S291 →	+0.608	+0.635	<.001	<.001	3	1
PDAC	RGS3_S917 →	-0.696	-0.985	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,371 associations by consensus.

PLCZ1 vs REEP4_S253 — PDAC

Explore this scatter interactively →