PLCZ1

Across TCGA patient cohorts, PLCZ1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLCZ1-associated genes across cancer lineages are Notch1, C-Raf, and EGFR_pY1068. Each is linked with PLCZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCZ1-to-partner and partner-to-PLCZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by PLCZ1-low versus PLCZ1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCZ1→partner) and Y-score (partner→PLCZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.136	+1.495	.006	.034	3	2
UCEC	C-Raf →	+0.121	+1.906	.017	.015	3	2
UCEC	EGFR_pY1068 →	-0.204	-2.000	.021	.029	3	1
UCEC	JNK_pT183_Y185 →	-0.145	-1.584	.015	.034	3	1
UCEC	MEK1 →	+0.429	+2.392	<.001	<.001	3	1
UCEC	Myosin-IIa_pS1943 →	+0.143	+1.375	.049	.024	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Notch1 by PLCZ1 expression — UCEC

Explore this box plot interactively →