PLCZ1

Across TCGA cell cohorts, PLCZ1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,022 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PLCZ1-associated GO terms across cancer lineages are Positive regulation of interleukin-8 production, Regulation of positive chemotaxis, and Positive regulation of positive chemotaxis. Each is linked with PLCZ1 in more than 5 cancer types. Because this analysis shows association rather than direction, both PLCZ1-to-partner and partner-to-PLCZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of interleukin-8 production grouped by PLCZ1-low versus PLCZ1-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCZ1→partner) and Y-score (partner→PLCZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Positive regulation of interleukin-8 production →	+0.094	+0.061	<.001	.004	3	6
SKIN	Regulation of positive chemotaxis →	+0.236	+0.043	<.001	.003	3	6
SKIN	Positive regulation of positive chemotaxis →	+0.245	+0.043	<.001	.003	3	6
SKIN	Positive regulation of nucleocytoplasmic transport →	+0.106	+0.043	<.001	.003	3	5
PANCREAS	Positive regulation of extracellular matrix disassembly →	+0.125	+0.050	<.001	.005	3	5
LUNG_NSCLC_LUAD	Urokinase plasminogen activator signaling pathway →	+0.402	+0.153	.008	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,022 associations by consensus.

Positive regulation of interleukin-8 production by PLCZ1 expression — SKIN

Explore this box plot interactively →