PLCZ1

Across TCGA cell cohorts, PLCZ1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLCZ1-associated genes across cancer lineages are KRTAP10-1, CER1, and TPRX1. Each is linked with PLCZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCZ1-to-partner and partner-to-PLCZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-1 grouped by PLCZ1-low versus PLCZ1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCZ1→partner) and Y-score (partner→PLCZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KRTAP10-1 →	+0.022	+5.209	<.001	.005	3	2
BLOOD_Lymphoma	CER1 →	+0.029	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	TPRX1 →	+0.006	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	DPPA3 →	+0.020	+6.247	<.001	<.001	3	1
SKIN	HMHB1 →	+0.038	+4.022	<.001	.006	3	1
CNS	FAM25G →	+0.746	+4.643	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

KRTAP10-1 by PLCZ1 expression — BLOOD_Lymphoma

Explore this box plot interactively →