PLCXD2

Across TCGA cell cohorts, PLCXD2 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLCXD2-associated genes across cancer lineages are PRAC1, SPINK6, and OR11H2. Each is linked with PLCXD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCXD2-to-partner and partner-to-PLCXD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAC1 grouped by PLCXD2-low versus PLCXD2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCXD2→partner) and Y-score (partner→PLCXD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PRAC1 →	+2.030	+3.832	.001	.003	3	1
BLOOD_Lymphoma	SPINK6 →	+0.602	+3.342	<.001	.008	3	1
BLOOD_Lymphoma	OR11H2 →	+0.019	+3.342	.002	.008	3	1
BLOOD_Lymphoma	OR2L8 →	+0.021	+3.584	<.001	.004	3	1
BLOOD_Leukemia	PRSS54 →	+0.027	+5.124	<.001	<.001	3	1
BLOOD_Leukemia	DEFA5 →	+0.231	+3.855	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

PRAC1 by PLCXD2 expression — BLOOD_Lymphoma

Explore this box plot interactively →