Across TCGA pan-cancer cohorts, PLCL2-AS1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of PLCL2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where PLCL2-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PLCL2-AS1 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

LUSC, KICH, and KIRP are the cancer types where PLCL2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLCL2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	−0.196	<.001	5	view →
KICH	All	IV	−0.297	.001	2	view →
KIRP	All	III,IV	−0.077	.044	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: PLCL2-AS1 RNA expression & survival · all PLCL2-AS1 data types