PLCH1-AS2

Across TCGA pan-cancer cohorts, PLCH1-AS2 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of PLCH1-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PLCH1-AS2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PLCH1-AS2 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, BLCA, and THCA are the cancer types where PLCH1-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLCH1-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.127	<.001	10	view →
BLCA	All	III,IV	+0.136	.004	7	view →
THCA	All	II,III,IV	−0.105	<.001	7	view →
STAD	All	All	+0.187	.001	6	view →
LUSC	All	All	+0.279	<.001	5	view →
LUAD	All	All	+0.210	.010	4	view →
KICH	All	II,III,IV	+0.043	.040	1	view →
KIRC	Male	All	+0.026	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

PLCH1-AS2–HNSC

Open the HNSC breakdown →