PLCH1-AS1

Across TCGA pan-cancer cohorts, PLCH1-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of PLCH1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PLCH1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PLCH1-AS1 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

THCA, LUSC, and KICH are the cancer types where PLCH1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLCH1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−0.144	<.001	8	view →
LUSC	All	All	−0.141	<.001	8	view →
KICH	Female	II,III,IV	+0.061	.013	4	view →
STAD	Male	All	+0.109	.011	3	view →
ESCA	All	II,III,IV	+0.240	.049	2	view →
KIRP	Female	All	+0.162	.002	2	view →
BLCA	All	III,IV	+0.042	.014	2	view →
KIRC	Male	All	+0.028	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

PLCH1-AS1–THCA

Open the THCA breakdown →