Across TCGA patient cohorts, PLCG2 protein abundance is significantly associated with the RNA expression of many other genes, with 21,743 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PLCG2-associated genes across cancer lineages are CSF2RB, CD28, and TRGV1. Each is linked with PLCG2 in more than 8 cancer types. Because this analysis shows association rather than direction, both PLCG2-to-partner and partner-to-PLCG2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCG2→partner) and Y-score (partner→PLCG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CSF2RB →	+1.249	+0.805	<.001	<.001	3	9
LSCC	CD28 →	+0.753	+0.488	<.001	<.001	3	9
HNSC	TRGV1 →	+1.330	+0.532	<.001	<.001	3	9
BRCA	MAP4K1 →	+1.008	+0.529	<.001	<.001	3	8
BRCA	CD37 →	+1.210	+0.577	<.001	<.001	3	8
GBM	RASAL3 →	+0.874	+0.713	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,743 associations by consensus.

Exploration

PLCG2 survival (RNA) · tumor vs normal (RNA) · all PLCG2 data types