Across TCGA patient cohorts, PLCG2 mutation is significantly associated with the RNA expression of many other genes, with 6,084 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLCG2-associated genes across cancer lineages are RPS12P15, SKA1, and ZNF367. Each is linked with PLCG2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLCG2-to-partner and partner-to-PLCG2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCG2→partner) and Y-score (partner→PLCG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RPS12P15 →	+0.099	+4.669	<.001	.007	3	4
UCEC	SKA1 →	+0.640	+2.828	<.001	<.001	3	4
STAD	ZNF367 →	+0.668	+3.496	.001	.002	3	4
UCEC	CLPX →	+0.313	+2.536	.002	<.001	3	4
UCEC	TIPIN →	+0.508	+1.828	<.001	<.001	3	4
UCEC	WDR62 →	+0.542	+1.389	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,084 associations by consensus.

Exploration

PLCG2 survival (RNA) · tumor vs normal (RNA) · all PLCG2 data types