PLCE1

Across TCGA patient cohorts, PLCE1 mutation is significantly associated with the total protein of many other genes, with 94 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLCE1-associated genes across cancer lineages are 4E-BP1, Acetyl-a-Tubulin-Lys40, and FASN. Each is linked with PLCE1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLCE1-to-partner and partner-to-PLCE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by PLCE1-low versus PLCE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCE1→partner) and Y-score (partner→PLCE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.278	+2.201	<.001	<.001	3	4
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.260	+1.147	.038	.025	3	4
LUAD	FASN →	+0.478	+3.321	.010	.009	3	3
UCEC	Ku80 →	+0.205	+1.705	<.001	<.001	3	3
STAD	eIF4E →	+0.215	+3.321	.011	.010	3	3
STAD	C-Raf →	+0.172	+3.000	.022	.034	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

4E-BP1 by PLCE1 expression — UCEC

Explore this box plot interactively →