PLCE1

Across TCGA pan-cancer cohorts, PLCE1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PLCE1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PLCE1 RNA is repressed in tumor relative to normal tissue. In most cancer types PLCE1 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and LIHC are the cancer types where PLCE1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLCE1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−2.261	<.001	12	view →
LUAD	Female	II,III,IV	−1.324	<.001	9	view →
LIHC	Female	II,III,IV	+0.815	<.001	9	view →
BRCA	All	III,IV	−0.781	<.001	8	view →
LUSC	Female	II,III,IV	−1.748	<.001	7	view →
READ	All	All	−1.717	<.001	7	view →
PAAD	Male	All	+1.315	.013	4	view →
KIRP	Male	All	−0.739	.012	4	view →
CHOL	Male	All	+1.608	<.001	3	view →
UCEC	All	All	−0.628	.047	2	view →
PRAD	All	All	−0.388	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PLCE1–COAD

Open the COAD breakdown →