PLCE1

Across TCGA cell cohorts, PLCE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,089 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PLCE1-associated GO terms across cancer lineages are Regulation of G1/S transition of mitotic cell cycle, Establishment of protein localization to vacuole, and Endosomal transport. Each is linked with PLCE1 in more than 10 cancer types. Because this analysis shows association rather than direction, both PLCE1-to-partner and partner-to-PLCE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of G1/S transition of mitotic cell cycle grouped by PLCE1-low versus PLCE1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCE1→partner) and Y-score (partner→PLCE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of G1/S transition of mitotic cell cycle →	+0.070	+1.626	<.001	.001	3	11
BREAST	Establishment of protein localization to vacuole →	+0.052	+1.224	.001	<.001	3	10
BONE	Endosomal transport →	+0.074	+1.909	<.001	<.001	3	10
OVARY	Regulation of cell cycle G1/S phase transition →	+0.066	+1.637	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Diacylglycerol biosynthetic process →	+0.126	+1.720	<.001	<.001	3	10
OESOPHAGUS	Vacuolar transport →	+0.059	+1.583	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,089 associations by consensus.

Regulation of G1/S transition of mitotic cell cycle by PLCE1 expression — BONE

Explore this box plot interactively →