PLCE1

Across TCGA cell cohorts, PLCE1 mutation is significantly associated with the RNA expression of many other genes, with 1,111 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLCE1-associated genes across cancer lineages are TAS1R2, TRIM51, and TP53AIP1. Each is linked with PLCE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCE1-to-partner and partner-to-PLCE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAS1R2 grouped by PLCE1-low versus PLCE1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCE1→partner) and Y-score (partner→PLCE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TAS1R2 →	+0.006	+4.017	<.001	.007	3	2
PANCREAS	TRIM51 →	+0.025	+4.614	<.001	.004	3	2
BLOOD_Lymphoma	TP53AIP1 →	+0.049	+3.754	.009	.002	3	2
BLOOD_Lymphoma	ZNF705G →	+0.004	+3.452	<.001	.004	3	2
LARGE_INTESTINE	PSMB2 →	+0.338	+2.584	.009	.002	3	2
LARGE_INTESTINE	METTL16 →	+0.532	+2.458	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,111 associations by consensus.

TAS1R2 by PLCE1 expression — OESOPHAGUS

Explore this box plot interactively →