PLCE1-AS1

Across TCGA pan-cancer cohorts, PLCE1-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PLCE1-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher PLCE1-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PLCE1-AS1 expression acts as an unfavorable survival marker, although some lineages such as UVM and STAD show a favorable association.

UVM, LGG, and KIRP are the cancer types where PLCE1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.752	0.443	.002	47	view →
LGG	DFS	Tertile	All	0.659	0.816	<.001	33	view →
KIRP	DFS	Tertile	All	0.600	0.811	.003	14	view →
STAD	OS	Tertile	IV	0.756	0.270	.034	12	view →
UCS	DFS	Tertile	IV	0.942	0.364	.024	12	view →
BRCA	OS	Quartile	III,IV	0.896	0.712	.005	11	view →
ACC	DFS	Tertile	III,IV	0.803	0.337	.008	10	view →
CHOL	DFS	Tertile	All	0.797	0.134	.028	9	view →
ESCA	DFS	Quartile	All	0.122	1.000	.004	9	view →
LUSC	OS	Tertile	All	0.600	0.796	.025	8	view →
GBM	OS	Tertile	All	0.619	0.347	.018	7	view →
SKCM	OS	Tertile	IV	0.168	0.818	.011	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PLCE1-AS1–UVM (DFS)

Open the UVM breakdown →