Across TCGA pan-cancer cohorts, PLCE1-AS1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of PLCE1-AS1’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where PLCE1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PLCE1-AS1 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.
COAD and CHOL are the cancer types where PLCE1-AS1 tumor–normal differential expression is most reproducible.