PLCD4

Across TCGA patient cohorts, PLCD4 mutation is significantly associated with the RNA expression of many other genes, with 4,446 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLCD4-associated genes across cancer lineages are RNA5SP277, MIR1183, and GLYATL3. Each is linked with PLCD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCD4-to-partner and partner-to-PLCD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP277 grouped by PLCD4-low versus PLCD4-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCD4→partner) and Y-score (partner→PLCD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP277 →	+0.504	+5.303	<.001	.006	3	2
HNSC	MIR1183 →	+0.737	+5.736	<.001	.003	3	2
UCEC	GLYATL3 →	+0.823	+1.360	<.001	.006	3	2
UCEC	ADAM33 →	-0.699	-3.034	.001	<.001	3	2
LUAD	PMM2P1 →	+0.126	+4.798	<.001	.006	3	2
CESC	LINC02876 →	+0.083	+5.010	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,446 associations by consensus.

RNA5SP277 by PLCD4 expression — HNSC

Explore this box plot interactively →