PLCD4

Across TCGA pan-cancer cohorts, PLCD4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PLCD4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PLCD4 RNA is repressed in tumor relative to normal tissue. In most cancer types PLCD4 is over-expressed in tumor, although a few such as KIRC and BLCA show the opposite, repressed pattern.

KIRC, BLCA, and THCA are the cancer types where PLCD4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLCD4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.769	<.001	12	view →
BLCA	Male	IV	−3.262	<.001	11	view →
THCA	Male	II,III,IV	−1.177	<.001	11	view →
LIHC	All	II,III,IV	+0.536	<.001	8	view →
COAD	All	II,III,IV	−0.656	<.001	7	view →
KIRP	Male	All	−0.514	<.001	6	view →
STAD	Female	All	−1.712	.001	4	view →
CHOL	All	All	+1.791	<.001	3	view →
READ	All	All	−1.102	.016	2	view →
PRAD	All	All	−0.431	<.001	2	view →
UCEC	All	All	−0.271	.046	2	view →
LUAD	Female	All	−0.164	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PLCD4–KIRC

Open the KIRC breakdown →