PLCD4

Across TCGA patient cohorts, PLCD4 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLCD4-associated genes across cancer lineages are JNK2, NDRG1_pT346, and Annexin-1. Each is linked with PLCD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCD4-to-partner and partner-to-PLCD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by PLCD4-low versus PLCD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCD4→partner) and Y-score (partner→PLCD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.197	+1.353	.001	.015	3	2
UCEC	NDRG1_pT346 →	-0.397	-2.222	.010	.009	3	2
UCEC	Annexin-1 →	+0.551	+2.341	<.001	.003	3	2
UCEC	STAT5a →	+0.262	+1.137	.037	.041	3	2
UCEC	ASNS →	+0.327	+1.353	.004	.015	3	2
UCEC	4E-BP1_pT37_T46 →	-0.251	-1.687	.033	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

JNK2 by PLCD4 expression — UCEC

Explore this box plot interactively →