PLCD4

Across TCGA cell cohorts, PLCD4 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLCD4-associated genes across cancer lineages are RGS21, INSL4, and RBMY1F. Each is linked with PLCD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCD4-to-partner and partner-to-PLCD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RGS21 grouped by PLCD4-low versus PLCD4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCD4→partner) and Y-score (partner→PLCD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RGS21 →	+0.044	+4.539	<.001	.007	3	1
SKIN	INSL4 →	+0.411	+3.791	<.001	.007	3	1
SKIN	RBMY1F →	+0.052	+4.437	<.001	.004	3	1
SKIN	TARM1 →	+0.724	+4.437	<.001	.004	3	1
SKIN	IFNL4 →	+0.032	+4.882	.008	<.001	3	1
SKIN	TP53TG3E →	+0.398	+4.347	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

RGS21 by PLCD4 expression — BLOOD_Leukemia

Explore this box plot interactively →