PLCB1

Across TCGA cell cohorts, PLCB1 mutation is significantly associated with the RNA expression of many other genes, with 604 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLCB1-associated genes across cancer lineages are KRTAP9-1, EIF4A1, and GLOD4. Each is linked with PLCB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLCB1-to-partner and partner-to-PLCB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP9-1 grouped by PLCB1-low versus PLCB1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLCB1→partner) and Y-score (partner→PLCB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KRTAP9-1 →	+0.020	+3.662	<.001	.009	3	2
LARGE_INTESTINE	EIF4A1 →	+0.529	+2.628	.003	.002	3	2
LARGE_INTESTINE	GLOD4 →	+0.616	+2.714	<.001	.002	3	2
LARGE_INTESTINE	SMYD4 →	+0.496	+2.389	.008	.006	3	2
OESOPHAGUS	NLRP5 →	+0.007	+4.432	<.001	<.001	3	1
OESOPHAGUS	RTP1 →	+0.023	+4.115	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 604 associations by consensus.

KRTAP9-1 by PLCB1 expression — BLOOD_Lymphoma

Explore this box plot interactively →