PLBD1-AS1

Across TCGA pan-cancer cohorts, PLBD1-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PLBD1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PLBD1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PLBD1-AS1 is over-expressed in tumor, although a few such as HNSC and KIRC show the opposite, repressed pattern.

HNSC, KIRC, and THCA are the cancer types where PLBD1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLBD1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	−1.372	<.001	10	view →
KIRC	Female	All	−0.772	<.001	10	view →
THCA	All	All	−0.496	<.001	8	view →
BRCA	All	III,IV	−0.736	<.001	6	view →
COAD	All	II,III,IV	−0.573	.001	6	view →
LUAD	Male	All	+0.852	<.001	5	view →
LIHC	All	II,III,IV	−0.347	.022	3	view →
PRAD	All	All	−1.411	<.001	2	view →
LUSC	All	All	+0.374	.014	2	view →
READ	All	II,III,IV	−0.652	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PLBD1-AS1–HNSC

Open the HNSC breakdown →