PLAU

Across TCGA patient cohorts, PLAU protein abundance is significantly associated with the RNA expression of many other genes, with 17,930 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLAU-associated genes across cancer lineages are PLAUR, FN1, and LGALS1. Each is linked with PLAU in more than 9 cancer types. Because this analysis shows association rather than direction, both PLAU-to-partner and partner-to-PLAU results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLAU versus PLAUR in CCRCC, with a Pearson correlation of 0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAU→partner) and Y-score (partner→PLAU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PLAUR →	+1.788	+1.251	<.001	<.001	3	10
OV	FN1 →	+2.091	+0.729	<.001	<.001	3	10
HNSC	LGALS1 →	+1.145	+0.499	<.001	<.001	3	9
LUAD	SLC2A1 →	+1.055	+0.541	<.001	<.001	3	9
BRCA	PODNL1 →	+1.071	+0.515	<.001	<.001	3	9
PDAC	LOXL2 →	+1.319	+0.869	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,930 associations by consensus.

PLAU vs PLAUR — CCRCC

Explore this scatter interactively →