PLAU

Across TCGA pan-cancer cohorts, PLAU RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of PLAU’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PLAU RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PLAU is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

HNSC, THCA, and BLCA are the cancer types where PLAU tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLAU RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+4.336	<.001	12	view →
THCA	Male	III,IV	+3.921	<.001	11	view →
BLCA	All	III,IV	+2.547	<.001	11	view →
COAD	Male	III,IV	+2.438	<.001	11	view →
KIRC	Female	II,III,IV	−2.103	<.001	11	view →
STAD	Male	II,III,IV	+2.512	<.001	10	view →
LUAD	Female	II,III,IV	+3.047	<.001	9	view →
KIRP	All	II,III,IV	−2.174	<.001	9	view →
LIHC	Female	II,III,IV	+1.679	<.001	9	view →
KICH	Female	II,III,IV	−5.098	<.001	8	view →
LUSC	Male	All	+2.698	<.001	8	view →
BRCA	All	III,IV	+1.451	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

PLAU–HNSC

Open the HNSC breakdown →