PLAU

Across TCGA cell cohorts, PLAU RNA expression is significantly associated with the go_rna of many other GO terms, with 5,886 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PLAU-associated GO terms across cancer lineages are Regulation of smooth muscle cell-matrix adhesion, Fibrinolysis, and Urokinase plasminogen activator signaling pathway. Each is linked with PLAU in more than 16 cancer types. Because this analysis shows association rather than direction, both PLAU-to-partner and partner-to-PLAU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of smooth muscle cell-matrix adhesion grouped by PLAU-low versus PLAU-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAU→partner) and Y-score (partner→PLAU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of smooth muscle cell-matrix adhesion →	+1.502	+3.600	<.001	<.001	3	17
BONE	Fibrinolysis →	+2.088	+4.414	<.001	<.001	3	17
BREAST	Urokinase plasminogen activator signaling pathway →	+1.308	+3.389	<.001	<.001	3	17
LUNG_NSCLC_LUAD	Cellular response to external stimulus →	+0.098	+3.918	<.001	<.001	3	15
BONE	Regulation of fibrinolysis →	+0.513	+3.729	<.001	<.001	3	15
SOFT_TISSUE	Positive regulation of canonical NF-kappaB signal transduction →	+0.063	+3.461	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,886 associations by consensus.

Regulation of smooth muscle cell-matrix adhesion by PLAU expression — STOMACH

Explore this box plot interactively →