PLAU

Across TCGA cell cohorts, PLAU mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLAU-associated genes across cancer lineages are ELOA3DP, KRT85, and KRT84. Each is linked with PLAU in more than 1 cancer types. Because this analysis shows association rather than direction, both PLAU-to-partner and partner-to-PLAU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOA3DP grouped by PLAU-low versus PLAU-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAU→partner) and Y-score (partner→PLAU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ELOA3DP →	+0.044	+4.273	<.001	.006	3	2
BLOOD_Leukemia	KRT85 →	+0.044	+4.539	<.001	.007	3	1
BLOOD_Leukemia	KRT84 →	+0.529	+4.152	<.001	.009	3	1
BLOOD_Leukemia	WFDC11 →	+0.030	+4.539	<.001	.007	3	1
BLOOD_Leukemia	REC114 →	+0.101	+4.409	<.001	.005	3	1
BLOOD_Leukemia	CDR1 →	+0.047	+5.060	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ELOA3DP by PLAU expression — LARGE_INTESTINE

Explore this box plot interactively →