PLAT

Across TCGA pan-cancer cohorts, PLAT mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PLAT data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PLAT mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PLAT expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where PLAT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	III,IV	0.985	0.709	.011	14	view →
PDAC	OS	Median	III,IV	0.321	0.565	.019	4	view →
CCRCC	DFS	Median	III,IV	0.722	0.430	.022	3	view →
LUAD	DFS	Median	All	0.945	0.560	.020	3	view →
LSCC	DFS	Quartile	All	1.000	0.830	.043	2	view →
GBM	DFS	Median	All	0.291	0.437	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PLAT–HNSC (OS)

Open the HNSC breakdown →