PLAT

Across TCGA pan-cancer cohorts, PLAT RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PLAT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PLAT RNA is repressed in tumor relative to normal tissue. In most cancer types PLAT is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where PLAT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLAT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−2.027	<.001	12	view →
KIRP	Male	All	−3.420	<.001	11	view →
KICH	Female	III,IV	−4.206	<.001	8	view →
UCEC	All	All	−2.532	<.001	8	view →
COAD	All	II,III,IV	−0.532	<.001	7	view →
LIHC	All	All	+0.587	<.001	6	view →
LUAD	Female	All	+1.176	.001	5	view →
LUSC	Male	All	+1.059	<.001	4	view →
BRCA	Female	All	−0.755	<.001	4	view →
CHOL	All	All	+1.997	<.001	3	view →
ESCA	Male	All	+1.758	.042	1	view →
BLCA	Female	IV	−1.606	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PLAT–KIRC

Open the KIRC breakdown →