PLAT

Across TCGA patient cohorts, PLAT protein abundance is significantly associated with the RNA expression of many other genes, with 13,407 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PLAT-associated genes across cancer lineages are BMERB1, NGFR, and CNN1. Each is linked with PLAT in more than 6 cancer types. Because this analysis shows association rather than direction, both PLAT-to-partner and partner-to-PLAT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLAT versus BMERB1 in OV, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAT→partner) and Y-score (partner→PLAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	BMERB1 →	+1.081	+0.714	<.001	<.001	3	7
LSCC	NGFR →	+1.271	+0.595	<.001	.002	2	7
UCEC	CNN1 →	+1.711	+0.557	<.001	<.001	3	6
UCEC	CALHM2 →	+0.735	+0.498	<.001	<.001	3	6
OV	FRMD6 →	+1.065	+0.677	<.001	.001	3	6
OV	FEZ1 →	+0.613	+0.712	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,407 associations by consensus.

PLAT vs BMERB1 — OV

Explore this scatter interactively →