PLAT

Across TCGA patient cohorts, PLAT mutation is significantly associated with the RNA expression of many other genes, with 2,266 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLAT-associated genes across cancer lineages are MIR615, BAG1, and H2AZ1. Each is linked with PLAT in more than 3 cancer types. Because this analysis shows association rather than direction, both PLAT-to-partner and partner-to-PLAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR615 grouped by PLAT-low versus PLAT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAT→partner) and Y-score (partner→PLAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR615 →	+0.169	+1.824	.002	.005	3	4
UCEC	BAG1 →	+0.408	+3.098	<.001	<.001	3	3
UCEC	H2AZ1 →	+0.468	+1.447	.003	.006	3	3
UCEC	PSMA4 →	+0.420	+1.676	<.001	.001	3	3
UCEC	FDFT1 →	+0.505	+1.522	<.001	.009	3	3
UCEC	ATP6V1B2 →	+0.425	+2.807	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,266 associations by consensus.

MIR615 by PLAT expression — UCEC

Explore this box plot interactively →