PLAT

Across TCGA patient cohorts, PLAT mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLAT-associated genes across cancer lineages are Src_pY527, Caspase-7-cleavedD198, and ACC1. Each is linked with PLAT in more than 2 cancer types. Because this analysis shows association rather than direction, both PLAT-to-partner and partner-to-PLAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY527 grouped by PLAT-low versus PLAT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAT→partner) and Y-score (partner→PLAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Src_pY527 →	-0.341	-2.459	.020	.018	3	3
COAD	Caspase-7-cleavedD198 →	+1.276	+2.824	.001	.034	3	2
UCEC	ACC1 →	+0.244	+1.887	.048	.029	3	2
UCEC	mTOR_pS2448 →	-0.136	-2.687	.007	.005	3	2
UCEC	Rictor_pT1135 →	-0.107	-1.807	.002	.025	3	2
UCEC	ATM →	-0.404	-1.247	.009	.045	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Src_pY527 by PLAT expression — UCEC

Explore this box plot interactively →