PLAT

Across TCGA cell cohorts, PLAT RNA expression is significantly associated with the go_rna of many other GO terms, with 4,765 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PLAT-associated GO terms across cancer lineages are Trans-synaptic signaling by BDNF, modulating synaptic transmission, Trans-synaptic signaling by BDNF, and Substrate adhesion-dependent cell spreading. Each is linked with PLAT in more than 18 cancer types. Because this analysis shows association rather than direction, both PLAT-to-partner and partner-to-PLAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Trans-synaptic signaling by BDNF, modulating synaptic transmission grouped by PLAT-low versus PLAT-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAT→partner) and Y-score (partner→PLAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Trans-synaptic signaling by BDNF, modulating synaptic transmission →	+1.437	+4.422	<.001	<.001	3	19
LUNG_NSCLC_LUAD	Trans-synaptic signaling by BDNF →	+1.437	+4.422	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Substrate adhesion-dependent cell spreading →	+0.277	+4.477	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Regulation of fibrinolysis →	+0.435	+4.080	<.001	.002	3	13
LUNG_NSCLC_LUSC	Negative regulation of fibrinolysis →	+0.440	+4.482	<.001	.001	3	13
LUNG_NSCLC_LUSC	Regulation of blood coagulation →	+0.270	+4.400	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,765 associations by consensus.

Trans-synaptic signaling by BDNF, modulating synaptic transmission by PLAT expression — LUNG_NSCLC_LUAD

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