PLAT

Across TCGA cell cohorts, PLAT mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLAT-associated genes across cancer lineages are OR1L4, SERPINB12, and KCND3. Each is linked with PLAT in more than 1 cancer types. Because this analysis shows association rather than direction, both PLAT-to-partner and partner-to-PLAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L4 grouped by PLAT-low versus PLAT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAT→partner) and Y-score (partner→PLAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR1L4 →	+0.022	+3.240	<.001	.004	3	1
LARGE_INTESTINE	SERPINB12 →	+0.095	+3.145	<.001	.004	3	1
LARGE_INTESTINE	KCND3 →	+0.456	+3.548	<.001	.004	3	1
LARGE_INTESTINE	PABPN1L →	+0.042	+3.639	<.001	<.001	3	1
BLOOD_Leukemia	CPXCR1 →	+0.054	+3.234	.002	.002	3	1
BLOOD_Leukemia	WNT3A →	+0.041	+3.697	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

OR1L4 by PLAT expression — LARGE_INTESTINE

Explore this box plot interactively →