PLAGL2

Across TCGA patient cohorts, PLAGL2 protein abundance is significantly associated with the RNA expression of many other genes, with 10,578 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLAGL2-associated genes across cancer lineages are PGGT1B, PURA, and CCNB1IP1. Each is linked with PLAGL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLAGL2-to-partner and partner-to-PLAGL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLAGL2 versus PGGT1B in BRCA, with a Pearson correlation of -0.73.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAGL2→partner) and Y-score (partner→PLAGL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PGGT1B →	-1.498	-1.457	<.001	.003	3	2
BRCA	PURA →	-1.521	-1.241	.001	.002	3	2
BRCA	CCNB1IP1 →	+1.245	+1.020	.003	.005	3	2
BRCA	IDS →	-1.105	-1.367	<.001	.004	3	2
BRCA	INPP4B →	-3.477	-1.451	<.001	.005	3	2
BRCA	BYSL →	+1.178	+1.385	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,578 associations by consensus.

PLAGL2 vs PGGT1B — BRCA

Explore this scatter interactively →