PLAGL2

Across TCGA pan-cancer cohorts, PLAGL2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PLAGL2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PLAGL2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PLAGL2 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

COAD, KICH, and STAD are the cancer types where PLAGL2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLAGL2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+1.129	<.001	11	view →
KICH	Female	II,III,IV	+2.157	<.001	9	view →
STAD	All	II,III,IV	+1.189	<.001	8	view →
HNSC	Male	All	+1.024	<.001	8	view →
LIHC	Female	II,III,IV	+1.158	<.001	7	view →
BLCA	All	III,IV	+0.766	.001	6	view →
THCA	All	All	−0.448	<.001	6	view →
BRCA	All	II,III,IV	+0.414	<.001	6	view →
LUSC	Male	All	+0.800	<.001	5	view →
CHOL	Male	All	+2.283	<.001	3	view →
READ	Female	All	+1.716	<.001	2	view →
KIRC	All	All	+0.232	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PLAGL2–COAD

Open the COAD breakdown →