PLAGL2

Across TCGA patient cohorts, PLAGL2 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLAGL2-associated genes across cancer lineages are p62 Lck ligand, EGFR_pY1068, and A-Raf_pS299. Each is linked with PLAGL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLAGL2-to-partner and partner-to-PLAGL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by PLAGL2-low versus PLAGL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAGL2→partner) and Y-score (partner→PLAGL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.375	+2.000	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.165	-1.584	.042	.034	3	1
UCEC	A-Raf_pS299 →	-0.115	-2.169	.002	.003	3	1
UCEC	ERK2 →	+0.137	+2.000	.027	.029	3	1
UCEC	Gab2 →	+0.358	+2.000	.001	<.001	3	1
UCEC	IGFBP2 →	-0.620	-2.000	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

p62 Lck ligand by PLAGL2 expression — UCEC

Explore this box plot interactively →