PLAGL2

Across TCGA cell cohorts, PLAGL2 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLAGL2-associated genes across cancer lineages are OR10G7, SEMG2, and TBC1D21. Each is linked with PLAGL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLAGL2-to-partner and partner-to-PLAGL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10G7 grouped by PLAGL2-low versus PLAGL2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAGL2→partner) and Y-score (partner→PLAGL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR10G7 →	+0.013	+6.357	<.001	<.001	3	2
LARGE_INTESTINE	SEMG2 →	+0.387	+2.878	.007	.009	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TEX33 →	+0.040	+3.297	<.001	.002	3	1
BLOOD_Lymphoma	APOBEC1 →	+0.018	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR14A16 →	+0.016	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

OR10G7 by PLAGL2 expression — CNS

Explore this box plot interactively →