PLAGL1

Across TCGA patient cohorts, PLAGL1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLAGL1-associated genes across cancer lineages are EGFR_pY1068, Bcl-xL, and eIF4E. Each is linked with PLAGL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLAGL1-to-partner and partner-to-PLAGL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PLAGL1-low versus PLAGL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAGL1→partner) and Y-score (partner→PLAGL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.256	-2.115	.003	.016	3	2
SKCM	Bcl-xL →	+0.190	+2.700	.017	.006	3	2
UCEC	eIF4E →	+0.182	+3.472	.012	.002	3	2
UCEC	GAPDH →	+0.413	+2.321	.026	.005	3	2
UCEC	ATM →	-0.546	-3.893	<.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.730	+3.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

EGFR_pY1068 by PLAGL1 expression — UCEC

Explore this box plot interactively →