PLAGL1

Across TCGA pan-cancer cohorts, PLAGL1 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated PLAGL1 data layer compared with 5 for mutation status.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher PLAGL1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PLAGL1 expression acts as an unfavorable survival marker, although some lineages such as UCS and ACC show a favorable association.

UCS, STAD, and UVM are the cancer types where PLAGL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	II,III,IV	0.520	0.068	<.001	70	view →
STAD	OS	Median	II,III,IV	0.444	0.638	.013	56	view →
UVM	OS	Median	III,IV	0.281	1.000	.003	55	view →
BLCA	DFS	Tertile	All	0.226	0.608	<.001	54	view →
ACC	DFS	Tertile	All	0.619	0.232	.001	51	view →
THCA	OS	Median	III,IV	0.942	1.000	.002	47	view →
LGG	OS	Tertile	All	0.413	0.600	<.001	33	view →
MESO	OS	Median	All	0.282	0.486	.002	29	view →
LUAD	DFS	Median	III,IV	0.505	0.812	.006	24	view →
OV	OS	Quartile	II,III,IV	0.799	0.881	.014	22	view →
KIRP	DFS	Quartile	II,III,IV	0.415	0.779	.020	19	view →
KICH	OS	Median	III,IV	0.416	0.917	.005	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

PLAGL1–UCS (DFS)

Open the UCS breakdown →