PLAGL1

Across TCGA cell cohorts, PLAGL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,233 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLAGL1-associated GO terms across cancer lineages are Protein folding, Potassium ion transport, and Ribosomal small subunit export from nucleus. Each is linked with PLAGL1 in more than 8 cancer types. Because this analysis shows association rather than direction, both PLAGL1-to-partner and partner-to-PLAGL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein folding grouped by PLAGL1-low versus PLAGL1-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAGL1→partner) and Y-score (partner→PLAGL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Protein folding →	+0.048	+2.372	<.001	<.001	3	9
STOMACH	Potassium ion transport →	-0.053	-1.831	.006	.001	3	9
LARGE_INTESTINE	Ribosomal small subunit export from nucleus →	+0.082	+1.977	<.001	<.001	3	9
OESOPHAGUS	Negative regulation of amyloid-beta clearance →	+0.127	+2.274	.002	.003	3	8
BLOOD_Lymphoma	Regulation of intracellular protein transport →	+0.059	+1.702	<.001	<.001	3	8
OESOPHAGUS	mRNA transport →	+0.089	+1.545	.009	.009	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,233 associations by consensus.

Protein folding by PLAGL1 expression — BLOOD_Leukemia

Explore this box plot interactively →