PLAGL1

Across TCGA cell cohorts, PLAGL1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLAGL1-associated genes across cancer lineages are AADACL3, IFNA7, and IFNA4. Each is linked with PLAGL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLAGL1-to-partner and partner-to-PLAGL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AADACL3 grouped by PLAGL1-low versus PLAGL1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAGL1→partner) and Y-score (partner→PLAGL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AADACL3 →	+0.012	+4.922	<.001	.009	3	1
BLOOD_Leukemia	IFNA7 →	+0.034	+4.922	<.001	.009	3	1
BLOOD_Leukemia	IFNA4 →	+0.055	+4.922	<.001	.009	3	1
BLOOD_Leukemia	MT1HL1 →	+0.560	+4.922	<.001	.009	3	1
LARGE_INTESTINE	TBX22 →	+0.030	+3.632	<.001	.003	3	1
LARGE_INTESTINE	COX6A2 →	+0.068	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

AADACL3 by PLAGL1 expression — BLOOD_Leukemia

Explore this box plot interactively →